Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | STK4 | Q13043 | 5/20 | 0.45 |
| ▸ | STK3 | Q13188 | 5/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107173 | 0.83 | FLT3 (0.46) | CCNT1CCNA2CDK2CDK9STK4 | |
| SCHEMBL4353306 | 0.82 | LRRK2 (0.62) | CCNT1CCNA2CDK2CDK9STK4 | |
| SCHEMBL3957730 | 0.80 | LRRK2 (0.71) | STK4STK3LRRK2CDK8MAP2K1 | |
| SCHEMBL12438584 | 0.80 | LRRK2 (0.55) | STK4STK3LRRK2MAP4K4NTRK1 | |
| SCHEMBL8114068 | 0.80 | ADK (0.49) | STK4STK3LRRK2 | |
| SCHEMBL4350720 | 0.80 | STK4 (0.68) | STK4STK3LRRK2MAP4K4 | |
| SCHEMBL8107168 | 0.80 | LRRK2 (0.62) | CCNT1CCNA2CDK2CDK9STK4 | |
| SCHEMBL7021288 | 0.78 | LRRK2 (0.63) | CDK2CDK9STK4STK3LRRK2 | |
| SCHEMBL7013879 | 0.76 | LRRK2 (0.65) | STK4STK3LRRK2MAP4K4NTRK1 | |
| SCHEMBL20162975 | 0.76 | RET (0.42) | CCNT1CCNA2CDK2CDK9STK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |
| WO-1997032879-A1 | 7-ALKYL-PYRROLO[2,3-d]PYRIMIDINES | NOVARTIS AG (CH) | 1997-09-12 | — | — | WO | disclosed |
| WO-1997028161-A1 | NOVEL PYRROLO[2,3-D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 1997-08-07 | — | — | WO | disclosed |