Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | YWHAG | P61981 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104619 | 0.89 | HRH4 (0.54) | HRH4HRH3ALDH1A1 | |
| SCHEMBL8119181 | 0.88 | HRH4 (0.61) | HRH4HRH3ALDH1A1 | |
| SCHEMBL8119207 | 0.82 | TDP1 (0.40) | HRH4HRH3TSHRALDH1A1 | |
| SCHEMBL7974587 | 0.80 | NPC1 (0.46) | TSHR | |
| Iodoproxyfan SCHEMBL3089477 | 0.78 | HRH3 (0.56) | HRH4HRH3 | |
| SCHEMBL4378557 | 0.77 | POLB (0.42) | HRH3L3MBTL1ALDH1A1 | |
| SCHEMBL6971280 | 0.77 | L3MBTL1 (0.44) | HRH4HRH3TSHRL3MBTL1YWHAG | |
| SCHEMBL5157531 | 0.76 | NAAA (0.35) | HRH4HRH3 | |
| Iodoproxyfan SCHEMBL3085830 | 0.76 | HRH3 (0.46) | HRH4HRH3 | |
| SCHEMBL14027508 | 0.75 | SPHK2 (0.34) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0597088-B1 | NOVEL IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATIONS | INST NAT SANTE RECH MED (FR) | 2000-12-06 | — | — | EP | claimed |
| EP-0994862-A2 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2000-04-26 | — | — | EP | claimed |
| WO-1999002502-A2 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 1999-01-21 | — | — | WO | claimed |