Sugi Predict

Sugi Predict / Compounds / SCHEMBL810756

SCHEMBL810756

SCHEMBL810756

CC(Br)c1ccc(Br)cc1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ CYP2A6 P11509 1/20 0.47
▸ ALDH1A1 P00352 2/20 0.43
▸ CYP1A2 P05177 1/20 0.43
▸ ALOX5 P09917 1/20 0.42
▸ PYCR1 P32322 1/20 0.41
▸ HTR2A P28223 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ SLC6A2 P23975 1/20 0.37
▸ SLC6A4 P31645 1/20 0.37
▸ SLC6A3 Q01959 1/20 0.37
▸ MAOA P21397 1/20 0.37
▸ ALOX15 P16050 2/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1415320 0.87 ESR1 (0.38) CYP1A2SLC6A2SLC6A3ALOX15
SCHEMBL16099537 0.80 CYP2A6 (0.44) CYP2A6ALDH1A1CYP1A2ALOX5PYCR1
SCHEMBL6911415 0.79 CYP2A6 (0.50) CYP2A6ALDH1A1CYP1A2ALOX5PYCR1
SCHEMBL254340 0.79 CYP2A6 (0.50) CYP2A6ALDH1A1CYP1A2ALOX5PYCR1
SCHEMBL5695686 0.79 TYR (0.46) ALDH1A1MAPK1
SCHEMBL9510147 0.79 PTGS2 (0.39) SLC6A2SLC6A4SLC6A3
SCHEMBL2400445 0.79 ESR1 (0.52) CYP2A6ALDH1A1CYP1A2ALOX5PYCR1
SCHEMBL31489555 0.77 ACHE (0.47) ALDH1A1ALOX5MAOA
SCHEMBL4434585 0.77 ACHE (0.47) ALDH1A1ALOX5MAOA
Magnesium SCHEMBL31125581 0.77 CYP2A6 (0.47) CYP2A6ALDH1A1CYP1A2ALOX5PYCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 231 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115385765-B Synthesis method of alkylaryl ketone 南京工业大学 2023-11-10 — — CN claimed
CN-114805152-B Synthetic method of thioamide 兰州大学 2023-04-14 — — CN claimed
CN-114805152-A Method for synthesizing thioamide 兰州大学 2022-07-29 — — CN claimed
CN-110343197-B Preparation method and antibacterial application of polymer type quaternary ammonium salt photocatalyst 浙江大学 2020-11-06 — — CN claimed
CN-110343197-A A kind of preparation method and its antibacterial application of polymeric quaternary ammonium salt photochemical catalyst 浙江大学 2019-10-18 — — CN claimed
JP-11116513-A — — None — — JP disclosed
US-20260041671-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS INC (US) 2026-02-12 — — US disclosed
US-12539292-B2 BRM targeting compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-02-03 — — US disclosed
US-20250353829-A1 BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF TEMPEST THERAPEUTICS INC (US) 2025-11-20 — — US disclosed
US-20250333429-A1 MODULATORS OF TNF-ALPHA ACTIVITY FORWARD THERAPEUTICS INC (US) 2025-10-30 — — US disclosed
EP-4622981-A1 MODULATORS OF TNF-ALPHA ACTIVITY Forward Therapeutics, Inc. (US) 2025-10-01 — — EP disclosed
US-12384808-B2 Modulators of TNF-α activity FORWARD THERAPEUTICS, INC. (US) 2025-08-12 — — US disclosed
US-6416861-B1 COMBINATORIAL CHEMISTRY NORTHWESTERN UNIVERSITY 2002-07-09 — — US disclosed
WO-2001070753-A1 SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS MERCK FROSST CANADA & CO. (CA) 2001-09-27 — — WO disclosed
WO-2000049022-A2 ORGANOSILICON COMPOUNDS AND USES THEREOF NORTHWESTERN UNIVERSITY (US) 2000-08-24 — — WO disclosed
JP-H11116513-A HIGHLY SELECTIVE PRODUCTION OF 4-BROMOSTYRENE TOSOH CORP 1999-04-27 — — JP disclosed
CN-1095721-A New compounds SMITHKLINE BEECHAM PLC (GB) 1994-11-30 — — CN disclosed
US-4633026-A DEHYDROHALOGENATION OF RING-HALOGENATED ALPHA- OR BETA-BROMOETHYL BENZENES WITH STRONG BASE, POLYOXYETHYLENE GLYCOL CATALYST, AMINE POLYMERIZATION INHIBITOR ETHYL CORPORATION (US) 1986-12-30 — — US disclosed
EP-0159915-A2 Process for making ring-halogenated styrenes and their use YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1985-10-30 — — EP disclosed
US-4423262-A Preparation of dibromostyrene ETHYL CORPORATION (US) 1983-12-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12539292-B2 BRM targeting compounds and associated methods of use ADRM1, SUMO2, BAZ1A CYP2A6 4194/4885ALDH1A1 3935/4885CYP1A2 4789/4885
US-12384808-B2 Modulators of TNF-α activity TNF, NFKBIA, TNFRSF1A CYP2A6 3968/4885ALDH1A1 2291/4885CYP1A2 3817/4885
US-20250353829-A1 BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF PTGER4, PTGER2, CNR2 CYP2A6 842/4885ALDH1A1 1392/4885CYP1A2 682/4885
US-20260041671-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ADRM1, VHL, BAZ1A CYP2A6 4179/4885ALDH1A1 3742/4885CYP1A2 4758/4885
US-20250333429-A1 MODULATORS OF TNF-ALPHA ACTIVITY TNF, NFKBIA, TNFRSF1A CYP2A6 3968/4885ALDH1A1 2563/4885CYP1A2 3971/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.