Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107425 | 0.93 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CBRD4LMNA | |
| SCHEMBL4316094 | 0.93 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CBRD4LMNA | |
| SCHEMBL8101449 | 0.83 | MYC (0.40) | ADRA2AADRA2BADRA2CLMNAKMT2A | |
| SCHEMBL8103457 | 0.82 | ALDH1A1 (0.44) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL9370180 | 0.81 | DRD2 (0.48) | ADRA2ABRD4LMNA | |
| SCHEMBL8107609 | 0.80 | BRD4 (0.36) | ADRA2AADRA2BADRA2CBRD4KMT2A | |
| SCHEMBL8299628 | 0.79 | BRD4 (0.45) | ADRA2AADRA2BADRA2CBRD4CYP3A4 | |
| SCHEMBL8093549 | 0.77 | BRD4 (0.39) | ADRA2AADRA2BADRA2CBRD4KMT2A | |
| SCHEMBL4321443 | 0.77 | — | — | |
| SCHEMBL8101881 | 0.77 | ALDH1A1 (0.43) | ADRA2AADRA2BADRA2CKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |