Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.33 |
| ▸ | GFER | P55789 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.32 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111931 | 0.78 | PSMB5 (0.38) | CHRM2NPC1CHRM4 | |
| SCHEMBL8114463 | 0.74 | CHRM4 (0.43) | CHRM4 | |
| SCHEMBL4573983 | 0.72 | HRH3 (0.42) | HRH3CHRM2NPC1CHRM4 | |
| SCHEMBL22796057 | 0.72 | JAK3 (0.47) | HRH3NPC1SMN1; SMN2MAPT | |
| SCHEMBL8097156 | 0.68 | SIGMAR1 (0.30) | — | |
| SCHEMBL8104817 | 0.68 | HSD11B1 (0.40) | — | |
| SCHEMBL4588673 | 0.68 | MAPT (0.47) | HRH3MAPK1MAPT | |
| SCHEMBL4588676 | 0.68 | MAPT (0.47) | HRH3MAPK1MAPT | |
| SCHEMBL19264139 | 0.66 | HRH3 (0.53) | HRH3GFERMAPK1IP6K1IP6K3 | |
| SCHEMBL8666063 | 0.66 | HSD17B10 (0.53) | HRH3MAPK1IP6K1IP6K3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |