Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573282 | 0.75 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL8109108 | 0.69 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL8107608 | 0.68 | HRH3 (0.40) | — | |
| SCHEMBL8111931 | 0.66 | PSMB5 (0.38) | — | |
| SCHEMBL4513999 | 0.65 | KDR (0.48) | — | |
| SCHEMBL8099271 | 0.65 | — | — | |
| SCHEMBL8114463 | 0.65 | CHRM4 (0.43) | — | |
| SCHEMBL8097201 | 0.63 | — | — | |
| SCHEMBL8114396 | 0.62 | CTSB (0.40) | — | |
| SCHEMBL21361440 | 0.62 | DRD2 (0.41) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |