Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP4 | P49662 | 1/20 | 0.42 |
| ▸ | CASP5 | P51878 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947935 | 1.00 | HPGD (0.46) | HPGDLSSKDM4EMEN1KMT2A | |
| SCHEMBL7270268 | 0.82 | SIGMAR1 (0.61) | KDM4EMEN1KMT2ATSHRSIGMAR1 | |
| SCHEMBL6945532 | 0.81 | CHRNB2 (0.64) | KDM4EDRD2ALDH1A1CASP1CASP4 | |
| SCHEMBL8099634 | 0.81 | CHRNB2 (0.64) | KDM4EDRD2ALDH1A1CASP1CASP4 | |
| SCHEMBL6943510 | 0.81 | ALDH1A1 (0.56) | LSSKDM4EMEN1KMT2ADRD2 | |
| SCHEMBL6949777 | 0.79 | ALDH1A1 (0.56) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL8108849 | 0.79 | ALDH1A1 (0.56) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL28269086 | 0.79 | LSS (0.66) | HPGDLSSKDM4EMEN1KMT2A | |
| SCHEMBL8113203 | 0.79 | KDM4E (0.61) | KDM4EHIF1AALDH1A1SIGMAR1POLB | |
| SCHEMBL6942215 | 0.79 | KDM4E (0.61) | KDM4EHIF1AALDH1A1SIGMAR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056744-A1 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | Aventis Pharmaceuticals Inc. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043675-A1 | 6,9-DISUBSTITUTED 2-[TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMACEUTICALS INC. (US) | 1999-09-02 | — | — | WO | disclosed |