Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.41 |
| ▸ | MMP13 | P45452 | 8/20 | 0.41 |
| ▸ | MMP9 | P14780 | 6/20 | 0.41 |
| ▸ | MMP2 | P08253 | 8/20 | 0.38 |
| ▸ | MMP3 | P08254 | 8/20 | 0.38 |
| ▸ | PDE4A | P27815 | 7/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | MMP16 | P51512 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943575 | 1.00 | MMP1 (0.41) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6941112 | 0.90 | MMP1 (0.47) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL7835803 | 0.83 | ADAM17 (0.36) | ADAM17 | |
| SCHEMBL6945043 | 0.82 | ADAM17 (0.35) | MMP2MMP3ADAM17 | |
| SCHEMBL6942458 | 0.82 | ADAM17 (0.37) | ADAM17 | |
| SCHEMBL6943368 | 0.82 | ADAM17 (0.37) | ADAM17 | |
| SCHEMBL6943954 | 0.81 | ADAM17 (0.35) | ADAM17 | |
| SCHEMBL6942237 | 0.81 | MMP1 (0.37) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6983531 | 0.78 | REN (0.41) | MMP1MMP2MMP3 | |
| SCHEMBL6986700 | 0.78 | PSMB5 (0.36) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |