Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 11/20 | 0.37 |
| ▸ | MMP2 | P08253 | 8/20 | 0.37 |
| ▸ | MMP3 | P08254 | 8/20 | 0.37 |
| ▸ | MMP13 | P45452 | 5/20 | 0.35 |
| ▸ | MMP9 | P14780 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 4/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947398 | 0.88 | ADAM17 (0.34) | MMP2MMP9CTSKALDH1A1 | |
| SCHEMBL6937840 | 0.88 | ADAM17 (0.34) | MMP2MMP9CTSKALDH1A1 | |
| SCHEMBL6983935 | 0.84 | CTSK (0.36) | MMP2MMP9CTSKMCHR1 | |
| SCHEMBL6941112 | 0.84 | MMP1 (0.47) | MMP1MMP2MMP3MMP13MMP9 | |
| SCHEMBL8107765 | 0.81 | MMP1 (0.41) | MMP1MMP2MMP3MMP13MMP9 | |
| SCHEMBL6943575 | 0.81 | MMP1 (0.41) | MMP1MMP2MMP3MMP13MMP9 | |
| SCHEMBL6940018 | 0.79 | MMP2 (0.33) | MMP1MMP2MMP3MMP13MMP9 | |
| SCHEMBL6947183 | 0.78 | ALDH1A1 (0.32) | MMP1MMP2MMP3MMP13MMP9 | |
| SCHEMBL6942243 | 0.77 | ADAM17 (0.40) | MMP1MMP2MMP3MMP13MMP9 | |
| SCHEMBL7955132 | 0.77 | ADAM17 (0.44) | MMP2MMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |