Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 4/20 | 0.45 |
| ▸ | CA1 | P00915 | 6/20 | 0.43 |
| ▸ | CA2 | P00918 | 6/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656894 | 0.90 | PTGS2 (0.58) | PTGS2EPAS1BRD4PTGS1CYP19A1 | |
| SCHEMBL9657018 | 0.85 | PTGS2 (0.58) | PTGS2EPAS1BRD4CYP19A1 | |
| SCHEMBL4575282 | 0.85 | SOS1 (0.55) | PTGS2SOS1CA1CA2CA9 | |
| SCHEMBL9658618 | 0.82 | PTGS2 (0.58) | PTGS2EPAS1BRD4PTGS1CYP19A1 | |
| SCHEMBL9656869 | 0.81 | PTGS2 (0.57) | PTGS2EPAS1BRD4 | |
| SCHEMBL8524487 | 0.81 | PTGS2 (0.59) | PTGS2EPAS1BRD4PTGS1 | |
| SCHEMBL16047515 | 0.81 | PTGS2 (0.62) | PTGS2EPAS1BRD4PTGS1 | |
| SCHEMBL9656825 | 0.81 | PTGS2 (0.54) | PTGS2BRD4 | |
| SCHEMBL9658665 | 0.81 | PTGS2 (0.54) | PTGS2EPAS1BRD4PTGS1CYP19A1 | |
| SCHEMBL9656909 | 0.80 | PTGS2 (0.56) | PTGS2EPAS1BRD4CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |