Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.54 |
| ▸ | BRD4 | O60885 | 12/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656894 | 0.83 | PTGS2 (0.58) | PTGS2BRD4CYP19A1EPAS1PTGS1 | |
| SCHEMBL8107798 | 0.81 | PTGS2 (0.56) | PTGS2BRD4CYP19A1EPAS1PTGS1 | |
| SCHEMBL9657018 | 0.80 | PTGS2 (0.58) | PTGS2BRD4EP300CYP19A1EPAS1 | |
| SCHEMBL9658618 | 0.80 | PTGS2 (0.58) | PTGS2BRD4EP300CYP19A1EPAS1 | |
| SCHEMBL8524487 | 0.79 | PTGS2 (0.59) | PTGS2BRD4EP300EPAS1PTGS1 | |
| SCHEMBL9655254 | 0.78 | PTGS2 (0.58) | PTGS2BRD4EP300SLC22A12TBXA2R | |
| SCHEMBL9656909 | 0.78 | PTGS2 (0.56) | PTGS2BRD4EP300CYP19A1EPAS1 | |
| SCHEMBL9657522 | 0.78 | PTGS2 (0.56) | PTGS2BRD4EP300CYP19A1EPAS1 | |
| SCHEMBL441676 | 0.77 | PTGS2 (0.55) | PTGS2BRD4EP300CYP1A2CYP3A4 | |
| SCHEMBL9656863 | 0.77 | PTGS2 (0.57) | PTGS2BRD4EP300SLC22A12TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273369-B1 | NEW ALKANESULFONANILIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-04 | — | — | EP | disclosed |
| US-4866091-A | ANTINFLAMMATORY AGENTS, ANALGESICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-09-12 | — | — | US | disclosed |