Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.59 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 8/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10416533 | 0.85 | PTGS2 (0.59) | PTGS2CCR2BRD4PTGS1MAPK8 | |
| SCHEMBL6378390 | 0.84 | PTGS1 (0.56) | PTGS2CCR2PTGS1NR3C1PGR | |
| SCHEMBL9656894 | 0.83 | PTGS2 (0.58) | PTGS2BRD4PTGS1EPAS1 | |
| SCHEMBL9658618 | 0.83 | PTGS2 (0.58) | PTGS2BRD4PTGS1MAPK8EP300 | |
| SCHEMBL9657018 | 0.83 | PTGS2 (0.58) | PTGS2BRD4EP300EPAS1MAPK14 | |
| SCHEMBL16047515 | 0.82 | PTGS2 (0.62) | PTGS2CCR2BRD4PTGS1MAPK8 | |
| SCHEMBL8107798 | 0.81 | PTGS2 (0.56) | PTGS2BRD4PTGS1EPAS1 | |
| SCHEMBL9656909 | 0.81 | PTGS2 (0.56) | PTGS2BRD4EP300EPAS1 | |
| SCHEMBL9656995 | 0.81 | PTGS2 (0.56) | PTGS2CCR2BRD4EP300MAPT | |
| SCHEMBL9655254 | 0.81 | PTGS2 (0.58) | PTGS2BRD4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |