Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.55 |
| ▸ | CTSB | P07858 | 13/20 | 0.55 |
| ▸ | CTSS | P25774 | 13/20 | 0.55 |
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8113151 | 0.78 | CTSB (0.55) | CTSKCTSBCTSS | |
| SCHEMBL8111374 | 0.75 | CTSB (0.59) | CTSKCTSBCTSS | |
| SCHEMBL8099548 | 0.74 | CTSK (0.68) | CTSKCTSBCTSS | |
| SCHEMBL8113087 | 0.74 | CTSK (0.65) | CTSKCTSBCTSS | |
| SCHEMBL8107689 | 0.72 | CTSB (0.57) | CTSKCTSBCTSS | |
| SCHEMBL4590330 | 0.69 | CTSB (0.77) | CTSKCTSBCTSS | |
| SCHEMBL20139542 | 0.66 | MGLL (0.51) | FAAH | |
| SCHEMBL13106499 | 0.66 | GRIN1 (0.58) | KDM4EL3MBTL1 | |
| SCHEMBL8104024 | 0.64 | CTSB (1.00) | CTSKCTSBCTSS | |
| SCHEMBL13106304 | 0.64 | MEN1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |