Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.53 |
| ▸ | CA1 | P00915 | 6/20 | 0.53 |
| ▸ | CA2 | P00918 | 6/20 | 0.53 |
| ▸ | CA9 | Q16790 | 6/20 | 0.53 |
| ▸ | CA4 | P22748 | 5/20 | 0.53 |
| ▸ | CA6 | P23280 | 5/20 | 0.53 |
| ▸ | CA5A | P35218 | 5/20 | 0.53 |
| ▸ | CA7 | P43166 | 5/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.53 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105044 | 0.84 | CA2 (0.54) | CA12CA1CA2CA9CA4 | |
| SCHEMBL8091331 | 0.84 | CA1 (0.49) | CA12CA1CA2CA9CA4 | |
| SCHEMBL8091465 | 0.82 | CA2 (0.54) | CA12CA1CA2CA9CA4 | |
| SCHEMBL8105269 | 0.81 | PTGS2 (0.48) | CA12CA1CA2CA9CA4 | |
| SCHEMBL8098834 | 0.80 | PDE7A (0.64) | CA12CA1CA2CA9CA4 | |
| SCHEMBL5806599 | 0.79 | CA2 (0.75) | CA12CA1CA2CA9CA4 | |
| SCHEMBL4962252 | 0.79 | MEN1 (0.53) | ALDH1A1HPGDCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8100934 | 0.77 | CA2 (0.44) | CA12CA1CA2CA9CA4 | |
| SCHEMBL8099561 | 0.77 | CA1 (0.56) | CA12CA1CA2CA9CA4 | |
| P-Chlorobenzenesulfonamide SCHEMBL31527679 | 0.71 | CA2 (1.00) | CA12CA1CA2CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |