Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSD | A5PKW4 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28958142 | 0.85 | NPC1 (0.56) | MAPTNPC1RAB9ARAD51MEN1 | |
| SCHEMBL8092460 | 0.83 | GRIN1 (0.55) | MAPTTP53THRBNPC1RAB9A | |
| SCHEMBL8106156 | 0.81 | PKM (0.45) | MAPTNPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL8099805 | 0.80 | NPC1 (0.58) | MAPTTP53NPC1RAB9ARAD51 | |
| SCHEMBL15175242 | 0.77 | ALDH1A3 (0.48) | MAPTTP53NPC1RAB9APKM | |
| SCHEMBL8092386 | 0.77 | NPC1 (0.55) | MAPTTP53THRBNPC1RAB9A | |
| SCHEMBL15175532 | 0.75 | ENPP2 (0.51) | MAPTTP53THRBKDM5BRAD51 | |
| SCHEMBL13325716 | 0.74 | RAB9A (0.81) | MAPTNPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL15175573 | 0.74 | FYN (0.39) | MAPTTP53THRBKDM5B | |
| SCHEMBL31314523 | 0.74 | FYN (0.39) | MAPTTP53THRBKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |