Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | RAD51 | Q06609 | 4/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PSD | A5PKW4 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108277 | 0.90 | RAD51 (0.55) | NPC1RAB9ARAD51MAPTALDH1A1 | |
| SCHEMBL8100020 | 0.86 | RAD51 (0.49) | NPC1RAB9ARAD51KDM5BMAPT | |
| SCHEMBL8102012 | 0.85 | KDM5B (0.48) | NPC1RAB9ARAD51KDM5BMAPT | |
| SCHEMBL7913582 | 0.83 | KDM4E (0.51) | NPC1RAB9ARAD51MAPTALDH1A1 | |
| SCHEMBL8101357 | 0.83 | HTT (0.49) | NPC1RAB9ARAD51KDM5BMAPT | |
| SCHEMBL8106201 | 0.81 | CTRC (0.45) | NPC1RAB9ARAD51ALDH1A1 | |
| SCHEMBL8099799 | 0.80 | NPC1 (0.51) | NPC1RAB9ARAD51MAPTALDH1A1 | |
| SCHEMBL8100226 | 0.77 | KDM4E (0.59) | NPC1RAB9ARAD51KDM5BMAPT | |
| SCHEMBL8092328 | 0.77 | KDM5B (0.47) | NPC1RAB9ARAD51KDM5BMAPT | |
| SCHEMBL8101679 | 0.76 | MEN1 (0.53) | NPC1RAB9AMAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |