Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099799 | 0.88 | NPC1 (0.51) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL8108081 | 0.86 | GAA (0.50) | KDM5BNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL8108178 | 0.85 | NPC1 (0.47) | KDM5BPDE10ANPC1RAB9APSD | |
| SCHEMBL8092328 | 0.84 | KDM5B (0.47) | KDM5BPDE10ANPC1RAB9AKMT2A | |
| SCHEMBL8101679 | 0.83 | MEN1 (0.53) | PDE10ANPC1RAB9AKMT2AMEN1 | |
| SCHEMBL8108277 | 0.80 | RAD51 (0.55) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL8106201 | 0.80 | CTRC (0.45) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL8102024 | 0.79 | ALDH1A1 (0.55) | KDM5BNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL8100020 | 0.77 | RAD51 (0.49) | KDM5BPDE10ANPC1RAB9AKMT2A | |
| SCHEMBL8102158 | 0.76 | NR1H4 (0.50) | KDM5BNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |