Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 11/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330463 | 0.86 | CACNA1F (0.43) | DDB1CRBNTP53CACNA1FCACNA1D | |
| SCHEMBL6348280 | 0.84 | CACNA1B (0.47) | CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7483319 | 0.82 | CACNA1B (0.50) | CACNA1B | |
| SCHEMBL8329610 | 0.80 | CACNA1F (0.58) | CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7660734 | 0.77 | ADRA1D (0.42) | — | |
| SCHEMBL8328481 | 0.75 | USP2 (0.58) | — | |
| SCHEMBL7481235 | 0.73 | NR1I2 (0.46) | CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL6137371 | 0.73 | ALDH1A1 (0.40) | DDB1CRBNCACNA1BCACNA1FCACNA1D | |
| SCHEMBL7483727 | 0.72 | CACNA1B (0.43) | CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL6339945 | 0.71 | CACNA1F (0.50) | CACNA1BTP53CACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986553-A4 | DIHYDROPYRIMIDONE DERIVATIVES AS NPY ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0986553-A1 | DIHYDROPYRIMIDONE DERIVATIVES AS NPY ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2000-03-22 | — | — | EP | disclosed |
| US-5889016-A | Dihydropyrimidone derivatives as NPY antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-30 | — | — | US | disclosed |
| WO-1998033791-A1 | DIHYDROPYRIMIDONE DERIVATIVES AS NPY ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-06 | — | — | WO | disclosed |