Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 6/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116085 | 0.83 | ALOX15 (0.41) | ALOX15KDM4CALDH1A1MAPTGSK3B | |
| SCHEMBL7501925 | 0.83 | PTGS2 (0.44) | ALOX15ALDH1A1MAPTL3MBTL1GSK3B | |
| SCHEMBL6171070 | 0.76 | PTGS2 (0.48) | ALOX15 | |
| SCHEMBL6171153 | 0.69 | TUBB4A (0.44) | ALOX15MDM2 | |
| SCHEMBL7506944 | 0.69 | GSK3B (0.40) | ALOX15KDM4CALDH1A1GSK3B | |
| SCHEMBL7507324 | 0.68 | ALOX15 (0.40) | ALOX15ALDH1A1MAPT | |
| SCHEMBL8137033 | 0.67 | ABCB11 (0.46) | ALOX15GSK3B | |
| SCHEMBL8117061 | 0.67 | ALOX15 (0.41) | ALOX15MDM2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL6170606 | 0.66 | PTGS2 (0.48) | MDM2KDM4CMAPT | |
| SCHEMBL7502692 | 0.66 | MEN1 (0.46) | ALOX15MDM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |