Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7044636 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL1788009 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL4857635 | 0.74 | MAPT (0.47) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL2360711 | 0.74 | MAPT (0.47) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL7044640 | 0.74 | HPGD (0.49) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL9300546 | 0.74 | MAPT (0.49) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL2210435 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL458419 | 0.72 | NPC1 (0.46) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL10691844 | 0.71 | SMN1; SMN2 (0.45) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL20260378 | 0.69 | MAPT (0.44) | SMN1; SMN2HPGDNPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |