Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458419 | 0.82 | NPC1 (0.46) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL6560509 | 0.78 | KDM4A (0.51) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL17279827 | 0.77 | GRM5 (0.48) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL2396469 | 0.74 | CYP11B1 (0.44) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL16073117 | 0.74 | NPC1 (0.47) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL6758198 | 0.74 | MEN1 (0.45) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL9542935 | 0.73 | HTT (0.43) | SMN1; SMN2HPGDTSHRNOTUMMAPT | |
| SCHEMBL6832118 | 0.72 | KCNJ1 (0.44) | SMN1; SMN2HPGDNPC1RAB9ATSHR | |
| SCHEMBL4549490 | 0.72 | HPGDS (0.50) | SMN1; SMN2HPGDNPC1RAB9AMAPT | |
| SCHEMBL2210435 | 0.71 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDNPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |