Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099356 | 0.73 | CTSB (0.47) | KCNH2CTSBCTSSCTSKPOLB | |
| SCHEMBL8099548 | 0.72 | CTSK (0.68) | KCNH2CTSBCTSSCTSKMEN1 | |
| SCHEMBL8112921 | 0.72 | CTSK (0.61) | KCNH2CTSBCTSSCTSK | |
| SCHEMBL8117173 | 0.71 | CTSK (0.50) | HRH3KCNH2CTSBCTSSCTSK | |
| SCHEMBL17665942 | 0.69 | ALDH1A1 (0.69) | HRH3KCNH2MEN1KMT2APOLB | |
| SCHEMBL2798033 | 0.67 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL8107285 | 0.67 | CTSB (0.69) | KCNH2CTSBCTSSCTSK | |
| SCHEMBL27739891 | 0.67 | HRH3 (0.64) | HRH3KCNH2MEN1KMT2APOLB | |
| SCHEMBL2798245 | 0.66 | HRH3 (0.97) | HRH3KCNH2 | |
| SCHEMBL4573152 | 0.66 | CTSB (0.67) | KCNH2CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |