Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.50 |
| ▸ | CTSB | P07858 | 4/20 | 0.50 |
| ▸ | CTSS | P25774 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111801 | 0.79 | RBP4 (0.51) | CTSKCTSBCTSS | |
| SCHEMBL8111646 | 0.74 | CTSK (0.58) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL8111806 | 0.74 | CTSK (0.57) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL8109815 | 0.74 | CTSK (0.69) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL8105988 | 0.74 | CTSK (0.69) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL8114117 | 0.74 | CTSK (0.60) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL30693168 | 0.72 | RAB9A (0.61) | RAB9ANPC1MAPTATMALDH1A1 | |
| SCHEMBL8110145 | 0.71 | HRH3 (0.50) | CTSKCTSBCTSSKCNH2HRH3 | |
| SCHEMBL2937126 | 0.71 | RAB9A (0.67) | RAB9ANPC1MAPTATMALDH1A1 | |
| SCHEMBL2937123 | 0.71 | RAB9A (0.67) | RAB9ANPC1MAPTATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |