Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.64 |
| ▸ | CTSB | P07858 | 12/20 | 0.64 |
| ▸ | CTSS | P25774 | 12/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 4/20 | 0.47 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099548 | 0.84 | CTSK (0.68) | CTSKCTSBCTSSKCNH2ADAM10 | |
| SCHEMBL8110058 | 0.83 | CTSK (0.56) | CTSKCTSBCTSSKCNH2ADAM10 | |
| SCHEMBL8107396 | 0.78 | CTSK (1.00) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL8108226 | 0.75 | CTSK (0.69) | CTSKCTSBCTSSMAPTSMN1; SMN2 | |
| SCHEMBL8113087 | 0.73 | CTSK (0.65) | CTSKCTSBCTSS | |
| SCHEMBL3631830 | 0.73 | CCR1 (0.60) | KCNH2CCR1MAPTSMN1; SMN2 | |
| SCHEMBL2876804 | 0.73 | CCR1 (0.60) | CCR1MAPTSMN1; SMN2 | |
| SCHEMBL8109989 | 0.71 | P2RX7 (0.43) | CTSKCTSBCTSSKCNH2ADAM10 | |
| SCHEMBL8110145 | 0.71 | HRH3 (0.50) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL3762797 | 0.70 | CCR1 (0.57) | KCNH2CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |