Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 8/20 | 0.43 |
| ▸ | CTSB | P07858 | 5/20 | 0.43 |
| ▸ | CTSS | P25774 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8110520 | 0.71 | CTSK (0.64) | CTSKCTSBCTSSKCNH2ADAM10 | |
| SCHEMBL8110145 | 0.70 | HRH3 (0.50) | CTSKCTSBCTSSKCNH2HRH3 | |
| SCHEMBL8110058 | 0.70 | CTSK (0.56) | CTSKCTSBCTSSKCNH2ADAM10 | |
| SCHEMBL8099548 | 0.67 | CTSK (0.68) | CTSKCTSBCTSSKCNH2ADAM10 | |
| SCHEMBL8117173 | 0.66 | CTSK (0.50) | CTSKCTSBCTSSKCNH2HRH3 | |
| SCHEMBL8107531 | 0.65 | CTSK (0.46) | CTSKCTSBCTSS | |
| SCHEMBL8099356 | 0.63 | CTSB (0.47) | CTSKCTSBCTSSKCNH2ADAM10 | |
| SCHEMBL8111801 | 0.63 | RBP4 (0.51) | CTSKCTSBCTSS | |
| SCHEMBL8111646 | 0.63 | CTSK (0.58) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL14899254 | 0.63 | MEN1 (0.54) | P2RX7KCNH2HRH3HRH1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |