Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7179143 | 0.85 | GABRA1 (0.38) | CYP1A2CYP3A4LMNAMAPT | |
| SCHEMBL7179138 | 0.85 | GABRA1 (0.38) | CYP1A2CYP3A4LMNAMAPT | |
| SCHEMBL13446821 | 0.79 | CYP2D6 (0.41) | CYP1A2CYP3A4CYP2D6NFKB1PNMT | |
| SCHEMBL3811810 | 0.76 | LMNA (0.41) | NFKB1LMNAALDH1A1GLAMAPT | |
| SCHEMBL1935211 | 0.75 | LMNA (0.50) | CYP1A2CYP3A4CYP2D6NFKB1PNMT | |
| SCHEMBL7659652 | 0.75 | KDM4E (0.38) | CYP1A2CYP3A4LMNAALDH1A1MAPT | |
| SCHEMBL8985163 | 0.74 | CA1 (0.53) | NFKB1LMNAALDH1A1MAPT | |
| SCHEMBL8985156 | 0.74 | CA1 (0.53) | NFKB1LMNAALDH1A1MAPT | |
| SCHEMBL7965579 | 0.73 | CYP1A2 (0.35) | CYP1A2CYP3A4CYP2D6LMNAALDH1A1 | |
| SCHEMBL4788211 | 0.71 | ALOX15 (0.38) | CYP1A2CYP3A4CYP2D6LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716661-B1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS INC (US) | 2000-04-05 | — | — | EP | disclosed |
| US-5552383-A | ANALGESIC, ANTIINFLAMMATORY FOR WOUNDS | SCIOS NOVA INC. (US) | 1996-09-03 | — | — | US | disclosed |
| US-5541286-A | Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids | SCIOS NOVA INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0716661-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1996-06-19 | — | — | EP | disclosed |
| WO-1995007294-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1995-03-16 | — | — | WO | disclosed |