SCHEMBL8113545

SCHEMBL8113545

Cc1cccc(-c2ccns2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NT5E P21589 1/20 0.46
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
ALDH1A1 P00352 2/20 0.42
NISCH Q9Y2I1 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
RAB9A P51151 3/20 0.42
ACHE P22303 1/20 0.41
NPC1 O15118 2/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
IDO1 P14902 1/20 0.40
METAP2 P50579 1/20 0.40
CHRNB4 P30926 1/20 0.39
CHRNA3 P32297 1/20 0.39
HSD17B1 P14061 1/20 0.38
HSD17B2 P37059 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9290080 0.79 CYP1A2 (0.53) NT5ECYP1A2CYP3A4CYP2D6ALDH1A1
SCHEMBL6422894 0.79 CYP3A4 (0.47) NT5ECYP1A2CYP3A4CYP2D6ALDH1A1
SCHEMBL3182746 0.77
SCHEMBL3467325 0.74 ALDH1A1 (0.43) NT5ECYP1A2CYP3A4CYP2D6ALDH1A1
SCHEMBL12266911 0.73 ALDH1A1 (0.46) ALDH1A1NISCHMEN1KMT2ARAB9A
SCHEMBL19741486 0.73 HSD17B1 (0.56) CYP3A4CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL147294 0.72 HSD17B1 (0.49) CYP3A4CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL9134795 0.72 IDO1 (0.42) ALDH1A1NISCHMEN1KMT2ARAB9A
SCHEMBL939733 0.72 KMO (0.53) ALDH1A1RAB9ANPC1HPGDSMN1; SMN2
SCHEMBL31471473 0.71 ACHE (0.69) ALDH1A1NISCHMEN1KMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0588917-B1 ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS THAT ENHANCE COGNITIVE FUNCTION ABBOTT LAB (US) 2000-11-08 EP disclosed
US-5409946-A Antiepileptic agent ABBOTT LABORATORIES (US) 1995-04-25 US disclosed
EP-0588917-A4 1994-04-13 EP disclosed
EP-0588917-A1 ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS THAT ENHANCE COGNITIVE FUNCTION ABBOTT LABORATORIES (US) 1994-03-30 EP disclosed
US-5234946-A Anticholesterol, antilipemic BANYU PHARMACEUTICAL CO., LTD. (JP) 1993-08-10 US disclosed
WO-1992021339-A1 ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS THAT ENHANCE COGNITIVE FUNCTION ABBOTT LABORATORIES (US) 1992-12-10 WO disclosed
EP-0395768-A1 SUBSTITUTED ALLYLAMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE BANYU PHARMACEUTICAL CO., LTD. (JP) 1990-11-07 EP disclosed