Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | TNF | P01375 | 5/20 | 0.45 |
| ▸ | AMPD2 | Q01433 | 2/20 | 0.45 |
| ▸ | EP300 | Q09472 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8113995 | 0.90 | FAAH (0.53) | FAAHMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8104256 | 0.89 | FAAH (0.63) | FAAHMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8113496 | 0.88 | PTGS2 (0.58) | FAAHMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9192919 | 0.84 | PTGS2 (0.59) | FAAHMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8113629 | 0.83 | MAPK14 (0.62) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL9195170 | 0.80 | PTGS2 (0.48) | FAAHMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8113890 | 0.78 | FAAH (0.51) | FAAHMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8118282 | 0.74 | FAAH (0.46) | FAAHTNFAMPD2EP300 | |
| SCHEMBL8112876 | 0.74 | PTGS2 (0.70) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL8104084 | 0.72 | MAPK14 (0.63) | MAPK13MAPK12MAPK11MAPK14PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| US-5663053-A | COENZYME A TRANSACYLASE FOR SCREENING | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5648373-A | CoA-IT and PAF inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-15 | — | — | US | disclosed |