Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8583548 | 0.84 | TSHR (0.35) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL8578786 | 0.81 | KDM4E (0.61) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL8122081 | 0.78 | ALDH1A1 (0.42) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL8124724 | 0.77 | KDM4E (0.38) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL8123737 | 0.75 | ALDH1A1 (0.42) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL8127824 | 0.71 | KCNH2 (0.39) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL8124327 | 0.71 | KDM4E (0.40) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL8607073 | 0.69 | KDM4E (0.49) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL8580755 | 0.69 | KDM4E (0.80) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL7297701 | 0.65 | ALDH1A1 (0.41) | ALDH1A1NPC1MAPTMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015450-A1 | NOVEL PYRIDAZINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-07-05 | — | — | EP | claimed |
| WO-1998009969-A1 | NOVEL ARYL-PYRIDAZINES | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-03-12 | — | — | WO | claimed |
| WO-1997045428-A1 | NOVEL PYRIDAZINE COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-12-04 | — | — | WO | claimed |
| EP-1015450-A1 | NOVEL PYRIDAZINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-07-05 | — | — | EP | disclosed |
| US-5935956-A | Pyridazine compounds | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-08-10 | — | — | US | disclosed |
| WO-1998009969-A1 | NOVEL ARYL-PYRIDAZINES | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-03-12 | — | — | WO | disclosed |
| WO-1997045428-A1 | NOVEL PYRIDAZINE COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-12-04 | — | — | WO | disclosed |