Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8115137 | 0.84 | KDM4E (0.40) | L3MBTL1PTGS2ALDH1A1NPSR1LMNA | |
| SCHEMBL8578786 | 0.70 | KDM4E (0.61) | L3MBTL1PTGS2ALDH1A1NPSR1LMNA | |
| SCHEMBL8124724 | 0.67 | KDM4E (0.38) | L3MBTL1PTGS2ALDH1A1NPSR1LMNA | |
| SCHEMBL8122081 | 0.66 | ALDH1A1 (0.42) | L3MBTL1ALDH1A1LMNAMAPTGAA | |
| SCHEMBL8115136 | 0.64 | KDM4E (0.43) | L3MBTL1ALDH1A1LMNAMAPTGAA | |
| SCHEMBL28835845 | 0.64 | PARP1 (0.49) | L3MBTL1ALDH1A1NPSR1GAARAB9A | |
| SCHEMBL8123737 | 0.64 | ALDH1A1 (0.42) | L3MBTL1ALDH1A1LMNAMAPTGAA | |
| SCHEMBL4370629 | 0.62 | PARP1 (0.64) | TSHRRXFP1L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL1259 | 0.62 | PARP1 (0.64) | TSHRRXFP1L3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL29351761 | 0.62 | PARP1 (0.64) | TSHRRXFP1L3MBTL1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998009969-A1 | NOVEL ARYL-PYRIDAZINES | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-03-12 | — | — | WO | disclosed |