Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 2/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | MMP14 | P50281 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11140990 | 0.86 | LTA4H (0.42) | MAPTALDH1A1TSHRMAOAMAOB | |
| SCHEMBL8121449 | 0.85 | LTA4H (0.44) | MAPTALDH1A1LTA4HCA2CA9 | |
| SCHEMBL8129500 | 0.78 | MAPK8 (0.36) | MAPTSLC6A4MAOBLTA4HPTGS2 | |
| SCHEMBL8116593 | 0.75 | ALDH1A1 (0.44) | MAPTSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL8129484 | 0.74 | LMNA (0.47) | ALDH1A1LTA4H | |
| SCHEMBL8124883 | 0.72 | ABCG2 (0.40) | MAPTSLC6A2SLC6A4SLC6A3CES2 | |
| SCHEMBL1068357 | 0.71 | — | — | |
| SCHEMBL1532077 | 0.71 | MAPT (0.42) | MAPTSLC6A2SLC6A4SLC6A3CES2 | |
| SCHEMBL8135193 | 0.70 | SLC6A2 (0.38) | MAPTSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3843978 | 0.68 | MAPT (0.74) | MAPTSLC6A2SLC6A4SLC6A3CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |