Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 3/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121673 | 0.81 | LMNA (0.47) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8129943 | 0.81 | LMNA (0.47) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11140990 | 0.79 | LTA4H (0.42) | ALDH1A1LTA4H | |
| SCHEMBL8117473 | 0.77 | LMNA (0.47) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23069170 | 0.77 | LMNA (0.44) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8123921 | 0.77 | LMNA (0.44) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8115367 | 0.77 | LMNA (0.44) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8121294 | 0.75 | LMNA (0.45) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8124447 | 0.74 | LMNA (0.47) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8116152 | 0.74 | MAPT (0.41) | ALDH1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |