Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508974 | 0.80 | ENPP2 (0.43) | KDM4EMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7506093 | 0.79 | KDM4E (0.47) | KDM4EMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7508178 | 0.78 | KDM4E (0.51) | KDM4EMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7506091 | 0.78 | KDM4E (0.44) | KDM4EMEN1KMT2ATP53ALOX15 | |
| SCHEMBL8120959 | 0.78 | PTGS2 (0.57) | — | |
| SCHEMBL7503293 | 0.77 | KDM4E (0.43) | KDM4EMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7501367 | 0.77 | KDM4E (0.65) | KDM4EMEN1KMT2A | |
| SCHEMBL7503003 | 0.77 | KDM4E (0.54) | KDM4EMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7504522 | 0.76 | KDM4E (0.42) | KDM4EMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7507514 | 0.76 | PTGS2 (0.44) | KDM4EMEN1KMT2ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |