Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 1/20 | 0.42 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116599 | 0.91 | PTPRB (0.46) | PTPRBTRPM8PGRPKMTP53 | |
| SCHEMBL8118990 | 0.87 | KAT8 (0.47) | KAT8MAPTLMNAALDH1A1PPARA | |
| SCHEMBL8126318 | 0.85 | PKM (0.40) | KAT8PKMMAPTKMT2AMEN1 | |
| SCHEMBL8109599 | 0.82 | PTPN2 (0.46) | PTPN22TP53MAPTKMT2AMEN1 | |
| SCHEMBL8119027 | 0.82 | PTPN22 (0.45) | PTPN22TRPM8NR3C1PGRPKM | |
| SCHEMBL8109933 | 0.81 | TRPM8 (0.42) | PTPRBTRPM8NR3C1PGRKAT8 | |
| SCHEMBL8124527 | 0.81 | PTPRB (0.43) | PTPRBPTPN22TRPM8NR3C1PGR | |
| SCHEMBL8119189 | 0.81 | PTPN22 (0.41) | PTPRBPTPN22TRPM8NR3C1PGR | |
| SCHEMBL8110912 | 0.81 | TRPM8 (0.42) | PTPRBPTPN22TRPM8NR3C1PGR | |
| SCHEMBL8117655 | 0.79 | GFER (0.41) | PTPRBKAT8MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036069-A1 | BENZENESULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999028306-A1 | BENZENESULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |