Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8124340 | 0.91 | KAT8 (0.44) | PTPRBTRPM8PTGESALOX5CXCR3 | |
| SCHEMBL8124141 | 0.85 | RAB9A (0.39) | PTGESALOX5CXCR3KMT2AKAT8 | |
| SCHEMBL8119189 | 0.83 | PTPN22 (0.41) | PTPRBTRPM8PTGESALOX5PGR | |
| SCHEMBL8120344 | 0.83 | PTPN22 (0.46) | TRPM8PTGESALOX5PGRNR3C1 | |
| SCHEMBL8110912 | 0.82 | TRPM8 (0.42) | PTPRBTRPM8PTGESALOX5PGR | |
| SCHEMBL8118480 | 0.81 | PTPRB (0.42) | PTPRBTRPM8PGRNR3C1PTPN22 | |
| SCHEMBL8109599 | 0.80 | PTPN2 (0.46) | PTPN22MEN1KMT2AMAPTTP53 | |
| SCHEMBL8116599 | 0.78 | PTPRB (0.46) | PTPRBTRPM8PGRMEN1KMT2A | |
| SCHEMBL8118852 | 0.77 | MEN1 (0.51) | MEN1KMT2ALMNAMAPTPKM | |
| SCHEMBL8109538 | 0.76 | PRSS1 (0.52) | TRPM8PTPN22MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036069-A1 | BENZENESULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999028306-A1 | BENZENESULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |