Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117483 | 0.83 | MTNR1A (0.58) | MTNR1AMTNR1BUSP2TSHRNPSR1 | |
| SCHEMBL8124550 | 0.83 | MTNR1A (0.48) | MTNR1AMTNR1BMAPTALDH1A1NPC1 | |
| SCHEMBL8132541 | 0.78 | MTNR1A (0.46) | MTNR1AMTNR1BMAPTUSP2TSHR | |
| SCHEMBL8131451 | 0.76 | MTNR1A (0.63) | MTNR1AMTNR1B | |
| SCHEMBL8123672 | 0.76 | MTNR1A (0.74) | MTNR1AMTNR1B | |
| SCHEMBL8133947 | 0.68 | MTNR1A (0.58) | MTNR1AMTNR1BMAPTALDH1A1NPC1 | |
| SCHEMBL11637718 | 0.67 | EYA3 (0.42) | MAPTUSP2TSHRALDH1A1HSD17B10 | |
| SCHEMBL8128784 | 0.67 | MTNR1A (0.60) | MTNR1AMTNR1B | |
| SCHEMBL8126457 | 0.65 | MTNR1A (0.53) | MTNR1AMTNR1BMAPTALDH1A1NPC1 | |
| SCHEMBL7756353 | 0.65 | TP53 (0.49) | MTNR1AMAPTUSP2TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147110-A | MELATONINERGIC AGENTS; SLEEP, EATING, CENTRAL NERVOUS SYSTEM, AND CARDIOVASCULAR DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-11-14 | — | — | US | disclosed |
| EP-0926145-A1 | Napthalene compounds, method for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-30 | — | — | EP | disclosed |