SCHEMBL8120146

SCHEMBL8120146

CC(C)(C)OC(=O)N1CCC(Oc2ccc(NC(=O)CNc3cc(C#N)ccc3CO[Si](C)(C)C(C)(C)C)cc2)CC1

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 6/20 0.52
CETP P11597 8/20 0.49
ALK Q9UM73 1/20 0.42
EPHX2 P34913 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8114017 0.86 GPR119 (0.59) GPR119CETPALK
SCHEMBL8113514 0.85 GPR119 (0.58) GPR119CETPALKEPHX2
SCHEMBL8115238 0.82 GPR119 (0.59) GPR119CETPALK
SCHEMBL8120896 0.81 GPR119 (0.52) GPR119CETPALK
SCHEMBL6188104 0.75 GPR119 (0.57) GPR119CETPALKEPHX2
SCHEMBL225375 0.74 GPR119 (0.91) GPR119ALK
SCHEMBL6192221 0.73 GPR119 (0.61) GPR119CETPALKEPHX2
SCHEMBL6959826 0.72 GPR119 (0.62) GPR119CETPALK
SCHEMBL8114242 0.72 FNTA (0.36)
SCHEMBL7343837 0.72 GPR119 (0.48) GPR119EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1020434-A1 3-AMIDINOANILINE DERIVATIVES, ACTIVATED BLOOD COAGULATION FACTOR X INHIBITORS, AND INTERMEDIATES FOR PRODUCING BOTH Kissei Pharmaceutical Co., Ltd. (JP) 2000-07-19 EP disclosed