Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20828281 | 0.90 | LMNA (0.74) | LMNAHSD17B10MEN1KMT2ATSHR | |
| SCHEMBL8133220 | 0.88 | PLA2G7 (0.67) | PLA2G7LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL8133945 | 0.86 | PLA2G7 (0.65) | PLA2G7LMNAHSD17B10GFERALDH1A1 | |
| SCHEMBL8135226 | 0.84 | PLA2G7 (0.63) | PLA2G7GFERALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8139957 | 0.82 | PLA2G7 (0.60) | PLA2G7GFERALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7741998 | 0.82 | PLA2G7 (0.60) | PLA2G7GFERALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7013476 | 0.82 | PLA2G7 (0.57) | PLA2G7KMT2AGFERALDH1A1SMN1; SMN2 | |
| SCHEMBL20828282 | 0.81 | MEN1 (0.75) | LMNAHSD17B10MEN1KMT2ATSHR | |
| SCHEMBL8139622 | 0.80 | PLA2G7 (0.58) | PLA2G7GFERALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8141713 | 0.80 | PLA2G7 (0.58) | PLA2G7GFERALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028955-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SmithKline Beecham p.l.c. (GB) | 2000-08-23 | — | — | EP | claimed |
| WO-1999024420-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 1999-05-20 | — | — | WO | claimed |