SCHEMBL812546

SCHEMBL812546

c1ccc2c(c1)-c1ccccc1C2[Zr]1(C2c3ccccc3-c3ccccc32)CC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.39
GPR3 P46089 2/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
NCOR2 Q9Y618 1/20 0.39
CYP1A2 P05177 2/20 0.38
CYP2D6 P10635 1/20 0.38
POLB P06746 1/20 0.38
BCHE P06276 1/20 0.36
ACHE P22303 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
TSHR P16473 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL10180148 0.98 HTR2A (0.38) HTR2AGPR3HDAC3HDAC4HDAC7
SCHEMBL8857182 0.80 DRD2 (0.33) GPR3POLBKMT2A
SCHEMBL8204623 0.79 PBRM1 (0.34) GPR3POLBKMT2A
SCHEMBL8857290 0.78 HTR6 (0.34) HTR2ACYP2D6
SCHEMBL6437792 0.78 GPR3 (0.32) GPR3POLBKMT2A
Hydrochloric Acid SCHEMBL6908083 0.78 PBRM1 (0.33) GPR3POLB
SCHEMBL6434163 0.76 BRD4 (0.34)
SCHEMBL4454304 0.67 GPR3 (0.46) HTR2AGPR3HDAC3HDAC4HDAC7
SCHEMBL58473 0.67 GPR3 (0.46) HTR2AGPR3HDAC3HDAC4HDAC7
SCHEMBL29950614 0.66 GPR3 (0.50) HTR2AGPR3HDAC3HDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2460834-B1 Improved acidic activator-supports and catalysts for olefin polymerization CHEVRON PHILLIPS CHEMICAL CO (US) 2015-08-12 EP claimed
EP-1807456-B1 ORGANOCHROMIUM/METALLOCENE COMBINATION CATALYST FOR PRODUCING BIMODAL RESINS CHEVRON PHILLIPS CHEMICAL CO (US) 2012-07-11 EP claimed
US-11618791-B2 Systems and methods for producing a supported catalyst EXXONMOBIL CHEMICAL PATENTS INC. (US) 2023-04-04 US disclosed
WO-2021108049-A1 SYSTEMS AND METHODS FOR PRODUCING A SUPPORTED CATALYST EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-06-03 WO disclosed
US-20210155723-A1 Systems and Methods for Producing a Supported Catalyst EXXONMOBIL CHEMICAL PATENTS INC (US) 2021-05-27 US disclosed
EP-2872539-B1 INCREASED POLYMER MELT FLOW RATIO VIA FEED OF A SUPPORTED CATALYST SATURATED WITH A SELECTED LIQUID AGENT UNIVATION TECH LLC (US) 2020-12-09 EP disclosed
US-9512254-B2 Increased polymer melt flow ratio via feed of a supported catalyst saturated with a selected liquid agent UNIVATION TECHNOLOGIES, LLC (US) 2016-12-06 US disclosed
EP-1716183-B1 DE-FOAMING SPRAY DRIED CATALYST SLURRIES UNIVATION TECH LLC (US) 2016-04-13 EP disclosed
EP-2872539-A1 INCREASED POLYMER MELT FLOW RATIO VIA FEED OF A SUPPORTED CATALYST SATURATED WITH A SELECTED LIQUID AGENT Univation Technologies, LLC (US) 2015-05-20 EP disclosed
US-20150133614-A1 Increased Polymer Melt Flow Ratio Via Feed of a Supported Catalyst Saturated With a Selected Liquid Agent UNIVATION TECHNOLOGIES, LLC (US) 2015-05-14 US disclosed
US-8633286-B2 Catalyst compositions comprising support materials having an improved particle-size distribution UNIVATION TECHNOLOGIES, LLC (US) 2014-01-21 US disclosed
US-20030171514-A1 Polymerization catalyst activator complexes and their use in a polymerization process DOW GLOBAL TECHNOLOGIES LLC 2003-09-11 US disclosed
WO-2003064435-A1 POLYMERIZATION CATALYST ACTIVATOR COMPLEXES AND THEIR USE IN A POLYMERIZATION PROCESS UNIVATION TECHNOLOGIES, LLC (US) 2003-08-07 WO disclosed
EP-0530908-B2 Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins DSM NV (NL) 2003-06-04 EP disclosed
EP-0927201-A1 CATALYST SYSTEM FOR (CO)POLYMERIZATION OF OLEFINS AND PROCESS FOR THE PREPARATION OF OLEFIN (CO)POLYMERS USING THE CATALYST SYSTEM Hyundai Petrochemical Co., Ltd. (KR) 1999-07-07 EP disclosed
EP-0530908-B1 Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins DSM NV (NL) 1999-04-21 EP disclosed
WO-1998009996-A1 CATALYST SYSTEM FOR (CO)POLYMERIZATION OF OLEFINS AND PROCESS FOR THE PREPARATION OF OLEFIN (CO)POLYMERS USING THE CATALYST SYSTEM HYUNDAI PETROCHEMICAL CO., LTD. (KR) 1998-03-12 WO disclosed
US-5646083-A Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins DSM N.V. (NL) 1997-07-08 US disclosed
EP-0530908-A1 Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins DSM N.V. (NL) 1993-03-10 EP disclosed
EP-0500944-A1 CATALYST FOR $g(a)-OLEFIN POLYMERIZATION AND PRODUCTION OF POLY-$g(a)-OLEFIN THEREWITH MITSUI TOATSU CHEMICALS, Inc. (JP) 1992-09-02 EP disclosed