SCHEMBL8125489

SCHEMBL8125489

CC(C)(C)OC(=O)N(N)c1ccc(C(=O)OCCCO)cn1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.36
CYP1A2 P05177 3/20 0.36
CYP3A4 P08684 2/20 0.36
TSHR P16473 2/20 0.36
CYP2C19 P33261 2/20 0.36
CYP2C9 P11712 1/20 0.36
PDE4D Q08499 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
GAA P10253 3/20 0.35
ALDH1A1 P00352 2/20 0.34
CYP2D6 P10635 2/20 0.34
MAPT P10636 2/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
CHRM2 P08172 1/20 0.34
HTR1A P08908 1/20 0.34
DRD3 P35462 1/20 0.34
SCN1A P35498 1/20 0.34
SLC6A3 Q01959 1/20 0.34
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2558802 0.79 HCAR3 (0.48) CYP1A2CYP2C19CYP2C9L3MBTL1ALDH1A1
SCHEMBL465766 0.74 SYK (0.47) LMNACYP1A2CYP3A4CYP2C19CYP2C9
SCHEMBL1509166 0.74 CRBN (0.36) MAPK1SRD5A1
SCHEMBL8723112 0.73 KDM4E (0.34) ALDH1A1RAB9ANR1H2POLB
SCHEMBL8125491 0.73 GAA (0.42) LMNACYP1A2TSHRCYP2C19L3MBTL1
SCHEMBL27977445 0.72 MAPT (0.49) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL6882614 0.70 MAPK1 (0.51) LMNAL3MBTL1GAAALDH1A1MAPT
SCHEMBL18291621 0.69 PPARA (0.41) LMNACYP1A2CYP3A4TSHRL3MBTL1
SCHEMBL7913868 0.69 CYP2C19 (0.49) LMNACYP1A2CYP2C19GAAALDH1A1
SCHEMBL1770925 0.68 HCAR3 (0.50) CYP1A2CYP2C19CYP2C9L3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0667859-B1 MOLECULE LABELLING USING 2-HYDRANINOPYRIDINE DERIVATIVES ANORMED INC (CA) 2000-08-23 EP disclosed
US-5679778-A FOR FORMING CONJUGATES WITH MACROMOLECULES JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 1997-10-21 US disclosed
EP-0667859-A1 MOLECULE LABELLING USING 2-HYDRANINOPYRIDINE DERIVATIVES JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 1995-08-23 EP disclosed
WO-1994010149-A1 MOLECULE LABELLING USING 2-HYDRANINOPYRIDINE DERIVATIVES JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 1994-05-11 WO disclosed