Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.42 |
| ▸ | TGM2 | P21980 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121355 | 0.88 | TGM2 (0.42) | FOLH1TGM2HTTSLC1A3SLC1A1 | |
| SCHEMBL8121290 | 0.86 | SLC1A3 (0.41) | FOLH1TGM2HTTSLC1A3SLC1A1 | |
| SCHEMBL8112530 | 0.81 | OPRM1 (0.44) | FOLH1HTTSLC1A3SLC1A1SMN1; SMN2 | |
| SCHEMBL8112045 | 0.81 | FOLH1 (0.45) | FOLH1TGM2HTTSLC1A3SLC1A1 | |
| SCHEMBL8119982 | 0.80 | FOLH1 (0.45) | FOLH1TGM2HTTSLC1A3SLC1A1 | |
| SCHEMBL4650760 | 0.80 | TRPV1 (0.41) | — | |
| SCHEMBL8119834 | 0.79 | CFTR (0.46) | FOLH1HTTSLC1A3SLC1A1 | |
| SCHEMBL8126814 | 0.79 | FOLH1 (0.48) | FOLH1TGM2HTTSLC1A3SLC1A1 | |
| SCHEMBL7801973 | 0.77 | MC3R (0.38) | — | |
| SCHEMBL8120934 | 0.77 | HTT (0.48) | FOLH1TGM2HTTSLC1A3SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680469-B1 | AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME | BOEHRINGER INGELHEIM PHARMA (DE) | 2000-04-26 | — | — | EP | disclosed |
| EP-0680469-A1 | AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME | Dr. Karl Thomae GmbH (DE) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994017035-A1 | AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME | DR. KARL THOMAE GMBH (DE) | 1994-08-04 | — | — | WO | disclosed |