SCHEMBL8128296

SCHEMBL8128296

[NH]C(=O)[C@H](N)c1ccc(O)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 9/20 0.41
ESR2 Q92731 8/20 0.41
PDCD1 Q15116 1/20 0.41
CD274 Q9NZQ7 1/20 0.41
TDP1 Q9NUW8 3/20 0.40
ALDH1A1 P00352 3/20 0.40
TAAR1 Q96RJ0 2/20 0.40
KMT2A Q03164 2/20 0.40
NFKB1 P19838 2/20 0.40
HIF1A Q16665 2/20 0.40
HTR3A P46098 1/20 0.40
GAA P10253 1/20 0.40
TSHR P16473 1/20 0.40
SRC P12931 1/20 0.39
SLC7A5 Q01650 1/20 0.39
ALOX15 P16050 3/20 0.39
KDM4E B2RXH2 3/20 0.39
APEX1 P27695 1/20 0.39
LMNA P02545 3/20 0.37
MAPT P10636 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3730444 1.00 ESR1 (0.41) ESR1ESR2PDCD1CD274TDP1
SCHEMBL11878994 0.82 TDP1 (0.37) TDP1ALDH1A1KMT2AHIF1ATSHR
SCHEMBL11216047 0.80 ALOX5 (0.44) TDP1ALDH1A1KMT2AGAALMNA
SCHEMBL11216605 0.80 HDAC3 (0.44) ALDH1A1LMNA
SCHEMBL11213779 0.80 KIF11 (0.43) ALDH1A1KMT2AHIF1AKDM4ELMNA
SCHEMBL11215605 0.80 ADRB2 (0.46) KMT2ANFKB1TSHRALOX15APEX1
SCHEMBL11548068 0.79 ESR1 (0.52) ESR1ESR2PDCD1CD274TDP1
Oxfenicine SCHEMBL652186 0.79 HSD17B10 (0.55) ESR1ESR2PDCD1CD274TDP1
SCHEMBL8545010 0.79 CYP2D6 (0.46) HIF1ASRCLMNACYP2D6
SCHEMBL8122334 0.79 CYP2D6 (0.46) HIF1ASRCLMNACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0366641-B1 Novel antimicrobial quinolonyl lactam esters NORWICH EATON PHARMA (US) 2000-07-05 EP disclosed
EP-0997466-A1 Novel antimicrobial lactam-quinolones PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) 2000-05-03 EP disclosed
EP-0775114-B1 PROCESS FOR MAKING ANTIMICROBIAL COMPOUNDS PROCTER & GAMBLE (US) 2000-03-22 EP disclosed
US-5656623-A BACTERICIDES; ANTIBIOTICS THE PROCTER & GAMBLE COMPANY (US) 1997-08-12 US disclosed
US-5648346-A Antimicrobial carbacephem-quinolones THE PROCTER & GAMBLE COMPANY (US) 1997-07-15 US disclosed
US-5646139-A TREATING AND PREVENTING INFECTION THE PROCTER & GAMBLE COMPANY (US) 1997-07-08 US disclosed
US-5637580-A ANTIBIOTICS THE PROCTER & GAMBLE COMPANY (US) 1997-06-10 US disclosed
EP-0775145-A1 PROCESS FOR MAKING QUINOLONYL LACTAM ANTIMICROBIALS AND NOVEL INTERMEDIATE COMPOUNDS THE PROCTER & GAMBLE COMPANY (US) 1997-05-28 EP disclosed
EP-0775114-A1 PROCESS FOR MAKING ANTIMICROBIAL COMPOUNDS THE PROCTER & GAMBLE COMPANY (US) 1997-05-28 EP disclosed
WO-1996004286-A9 PROCESS FOR MAKING QUINOLONYL LACTAM ANTIMICROBIALS AND NOVEL INTERMEDIATE COMPOUNDS 1997-05-22 WO disclosed
EP-0525057-A4 ANTIMICROBIAL QUINOLONYL LACTAMS 1993-04-07 EP disclosed
EP-0525057-A1 ANTIMICROBIAL QUINOLONYL LACTAMS Norwich Eaton Pharmaceuticals, Inc. (US) 1993-02-03 EP disclosed
US-5180719-A Microbiocides NORWICH EATON PHARMACEUTICALS, INC. (US) 1993-01-19 US disclosed
WO-1991016327-A1 ANTIMICROBIAL QUINOLONYL LACTAMS NORWICH EATON PHARMACEUTICALS, INC. (US) 1991-10-31 WO disclosed
WO-1990004594-A1 NOVEL ANTIMICROBIAL QUINOLONYL LACTAM ESTERS NORWICH EATON PHARMACEUTICALS, INC. (US) 1990-05-03 WO disclosed
WO-1990004595-A1 NOVEL ANTIMICROBIAL FLUOROQUINOLONYL CEPHEMS NORWICH EATON PHARMACEUTICALS, INC. (US) 1990-05-03 WO disclosed
EP-0366193-A2 Novel antimicrobial quinolonyl lactams Norwich Eaton Pharmaceuticals, Inc. (US) 1990-05-02 EP disclosed
EP-0366641-A2 Novel antimicrobial quinolonyl lactam esters Norwich Eaton Pharmaceuticals, Inc. (US) 1990-05-02 EP disclosed
EP-0366640-A2 Novel antimicrobial fluoroquinolonyl cephems Norwich-Eaton Pharmaceuticals, Inc. (US) 1990-05-02 EP disclosed
EP-0366189-A2 Novel antimicrobial lactam-quinolones Norwich Eaton Pharmaceuticals, Inc. (US) 1990-05-02 EP disclosed