Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 16/20 | 0.54 |
| ▸ | HTR1B | P28222 | 16/20 | 0.54 |
| ▸ | HTR1A | P08908 | 15/20 | 0.54 |
| ▸ | HTR2C | P28335 | 8/20 | 0.54 |
| ▸ | HTR2A | P28223 | 8/20 | 0.54 |
| ▸ | HTR6 | P50406 | 6/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129363 | 0.80 | NPC1 (0.58) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8133515 | 0.79 | HTR1D (0.55) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8402123 | 0.79 | HTR1D (0.65) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8122186 | 0.77 | MEN1 (0.60) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL7525124 | 0.77 | HTR1D (0.66) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL2931928 | 0.76 | KEAP1 (0.47) | KEAP1NFE2L2 | |
| SCHEMBL8400880 | 0.76 | HTR1D (0.79) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL5827584 | 0.76 | HTR1D (0.64) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8399188 | 0.76 | HTR1D (0.67) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8133761 | 0.75 | KMT2A (0.62) | HTR1DHTR1BHTR1AHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975614-A1 | A BICYCLIC ARYL OR A BICYCLIC HETEROCYCLIC RING CONTAINING COMPOUNDS HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | claimed |
| WO-1998047885-A1 | A BICYCLIC ARYL OR A BICYCLIC HETEROCYCLIC RING CONTAINING COMPOUNDS HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-10-29 | — | — | WO | claimed |
| US-6159979-A | Bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5HT1A, 5HT1B and 5HT1D receptor antagonistic activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-12-12 | — | — | US | disclosed |
| EP-0975614-A1 | A BICYCLIC ARYL OR A BICYCLIC HETEROCYCLIC RING CONTAINING COMPOUNDS HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998047885-A1 | A BICYCLIC ARYL OR A BICYCLIC HETEROCYCLIC RING CONTAINING COMPOUNDS HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-10-29 | — | — | WO | disclosed |