Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | MAX | P61244 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129106 | 1.00 | MEN1 (0.47) | MEN1KMT2AMAPTHTTNPSR1 | |
| SCHEMBL8129009 | 0.87 | ATG4B (0.45) | MEN1KMT2AMAPTLMNAHPGD | |
| SCHEMBL8129006 | 0.87 | ATG4B (0.45) | MEN1KMT2AMAPTLMNAHPGD | |
| SCHEMBL8134160 | 0.82 | TP53 (0.47) | MEN1KMT2AMAPTHTTNPSR1 | |
| SCHEMBL8134161 | 0.82 | TP53 (0.47) | MEN1KMT2AMAPTHTTNPSR1 | |
| SCHEMBL3305997 | 0.77 | MYC (0.74) | MEN1KMT2AMAPTHTTNPSR1 | |
| SCHEMBL8129144 | 0.72 | P2RX1 (0.39) | MEN1KMT2AMAPTP2RX1LMNA | |
| SCHEMBL8129143 | 0.72 | P2RX1 (0.39) | MEN1KMT2AMAPTP2RX1LMNA | |
| SCHEMBL8138760 | 0.72 | ALDH1A1 (0.41) | MEN1KMT2AMAPTHTTP2RX1 | |
| SCHEMBL8138758 | 0.72 | ALDH1A1 (0.41) | MEN1KMT2AMAPTHTTP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | disclosed |