Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.45 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.44 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.43 |
| ▸ | RORA | P35398 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8134160 | 1.00 | TP53 (0.47) | TP53MAPTTHRBKCNJ5KCNJ3 | |
| SCHEMBL8136466 | 0.85 | RAB9A (0.46) | TP53MAPTKCNJ5KCNJ3SMN1; SMN2 | |
| SCHEMBL8136468 | 0.85 | RAB9A (0.46) | TP53MAPTKCNJ5KCNJ3SMN1; SMN2 | |
| SCHEMBL8129106 | 0.82 | MEN1 (0.47) | MAPTP2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL8129109 | 0.82 | MEN1 (0.47) | MAPTP2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL3304422 | 0.77 | MYC (0.67) | TP53MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8129144 | 0.73 | P2RX1 (0.39) | MAPTP2RX1TMPRSS4KMT2AMEN1 | |
| SCHEMBL8129143 | 0.73 | P2RX1 (0.39) | MAPTP2RX1TMPRSS4KMT2AMEN1 | |
| SCHEMBL8138758 | 0.73 | ALDH1A1 (0.41) | MAPTP2RX1TMPRSS4SMN1; SMN2KMT2A | |
| SCHEMBL8138760 | 0.73 | ALDH1A1 (0.41) | MAPTP2RX1TMPRSS4SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | disclosed |