Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | GALR3 | O60755 | 2/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129105 | 0.77 | HDAC1 (0.56) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8131553 | 0.76 | HDAC1 (0.54) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL9302296 | 0.76 | PTAFR (0.52) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL9303746 | 0.75 | PTAFR (0.67) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8137536 | 0.75 | TNF (0.59) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8120441 | 0.75 | PTAFR (0.53) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8134171 | 0.75 | TNF (0.53) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8129576 | 0.75 | PTAFR (0.53) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8129274 | 0.75 | ADAM17 (0.42) | ADAM17 | |
| SCHEMBL8132114 | 0.75 | RECQL (0.49) | PTAFRHDAC1HDAC6GALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543858-B1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIOTECH PHARM (GB) | 2000-12-20 | — | — | EP | claimed |
| EP-0543858-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1993-06-02 | — | — | EP | claimed |
| WO-1992003423-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-03-05 | — | — | WO | claimed |
| EP-0543858-B1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIOTECH PHARM (GB) | 2000-12-20 | — | — | EP | disclosed |
| US-5451676-A | Treatment of hypotension and bronchoconstriction | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-09-19 | — | — | US | disclosed |
| US-5274094-A | Diseases or conditions mediated by platelet-activating factor; cyclization of a diamino compound with a carboxylic acid | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-12-28 | — | — | US | disclosed |
| EP-0543858-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| US-5200412-A | Antiinflammatory agents and antiallergens | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-04-06 | — | — | US | disclosed |
| WO-1992003423-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-03-05 | — | — | WO | disclosed |