Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.41 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5913948 | 0.87 | ALDH1A1 (0.52) | ALDH1A1LMNAHCAR3KMT2AHTT | |
| SCHEMBL12326836 | 0.83 | MAPT (0.51) | ALDH1A1LMNAHCAR3CHEK1KMT2A | |
| SCHEMBL3855174 | 0.83 | CASP6 (0.64) | LMNAHCAR3KMT2ATSHRCASP6 | |
| SCHEMBL3847201 | 0.81 | PARP1 (0.59) | ALDH1A1LMNACHEK1KMT2AHTT | |
| SCHEMBL16960436 | 0.81 | CHEK1 (0.47) | ALDH1A1LMNAHCAR3CHEK1KMT2A | |
| SCHEMBL5914014 | 0.80 | TSHR (0.68) | ALDH1A1LMNAHCAR3KMT2AHTT | |
| SCHEMBL8129502 | 0.79 | VCAM1 (0.63) | ALDH1A1LMNACHEK1KMT2AERN1 | |
| SCHEMBL8149078 | 0.79 | CHEK1 (0.55) | ALDH1A1LMNAHCAR3CHEK1KMT2A | |
| SCHEMBL22115119 | 0.78 | LMNA (0.66) | ALDH1A1LMNAHCAR3KMT2AHTT | |
| SCHEMBL31272847 | 0.78 | VCAM1 (0.68) | ALDH1A1LMNAKMT2AHSP90AA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763524-B1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-6040339-A | TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA OR ARTERIOSCLEROSIS IN A MAMMAL | SANKYO COMPANY, LIMITED (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5880147-A | Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use | SANKYO COMPANY, LIMITED (JP) | 1999-03-09 | — | — | US | disclosed |
| EP-0763524-A1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO COMPANY LIMITED (JP) | 1997-03-19 | — | — | EP | disclosed |