Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 8/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361562 | 0.77 | MAP4K4 (0.44) | MAP4K4ADORA2AADORA1CHRNB2CHRNA4 | |
| SCHEMBL6545410 | 0.76 | ADORA2A (0.50) | MAP4K4ADORA2AADORA1CHRNB2CHRNA4 | |
| SCHEMBL7758020 | 0.76 | MAP4K4 (0.46) | MAP4K4ADORA2AADORA1CHRNB2CHRNA4 | |
| SCHEMBL8124774 | 0.75 | P2RX3 (0.43) | KDM4EMEN1KMT2A | |
| SCHEMBL2754352 | 0.75 | SMN1; SMN2 (0.39) | KDM4EMEN1KMT2A | |
| SCHEMBL2752366 | 0.74 | SMN1; SMN2 (0.46) | KDM4EMEN1KMT2A | |
| SCHEMBL2752776 | 0.73 | TRPA1 (0.39) | MAP4K4KDM4EMEN1KMT2A | |
| SCHEMBL8125135 | 0.73 | ALDH1A1 (0.41) | KDM4EMEN1KMT2A | |
| SCHEMBL8125699 | 0.73 | MAP4K4 (0.43) | MAP4K4ADORA2AADORA1CHRNB2CHRNA4 | |
| SCHEMBL2751330 | 0.71 | HSPB1 (0.34) | MAP4K4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |