Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8237907 | 0.89 | PKM (0.56) | NPC1RAB9ACASP1ALDH1A1MAPT | |
| SCHEMBL13294049 | 0.89 | RAB9A (0.55) | NPC1RAB9ACASP1TSHRALDH1A1 | |
| SCHEMBL13294050 | 0.89 | HPGD (0.63) | NPC1RAB9ACASP1TSHRALDH1A1 | |
| SCHEMBL813404 | 0.86 | RAB9A (0.52) | NPC1RAB9ACASP1TSHRALDH1A1 | |
| SCHEMBL1614890 | 0.84 | TDP1 (0.55) | NPC1RAB9ATSHRALDH1A1MAPT | |
| SCHEMBL2354864 | 0.82 | RAB9A (0.57) | NPC1RAB9ACASP1TSHRALDH1A1 | |
| Ethylene Glycol SCHEMBL3446601 | 0.81 | TDP1 (0.55) | NPC1RAB9ATSHRALDH1A1MAPT | |
| SCHEMBL14231643 | 0.80 | RAB9A (0.50) | NPC1RAB9ATSHRALDH1A1MAPT | |
| SCHEMBL206554 | 0.79 | TDP1 (0.61) | NPC1RAB9ATSHRALDH1A1MAPT | |
| SCHEMBL8238907 | 0.79 | PKM (0.58) | NPC1RAB9ACASP1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968668-B2 | Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant | ETHICON INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-20070167617-A1 | Method of making a diisocyanate terminated macromer | ETHICON, INC. | 2007-07-19 | — | — | US | disclosed |