Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.41 |
| ▸ | TTPA | P49638 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120463 | 0.88 | TTPA (0.48) | PSEN1TTPAHTTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL8131330 | 0.86 | TTPA (0.44) | PSEN1TTPAALOX5 | |
| SCHEMBL8135291 | 0.80 | HTT (0.40) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL8126095 | 0.77 | ACHE (0.48) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL11701054 | 0.75 | PSEN1 (0.56) | PSEN1TTPAALOX5 | |
| Dimethylamine SCHEMBL8131335 | 0.74 | TTPA (0.53) | PSEN1TTPAALOX5MEN1KMT2A | |
| SCHEMBL8131088 | 0.73 | PTGS1 (0.49) | PSEN1TTPAALOX5 | |
| SCHEMBL2140140 | 0.72 | PSEN1 (0.53) | PSEN1TTPAALOX5 | |
| SCHEMBL2140130 | 0.72 | PSEN1 (0.53) | PSEN1TTPAALOX5 | |
| SCHEMBL8124729 | 0.71 | KMT2A (0.49) | ALOX5HTTSMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006108-A1 | 3-Hydroxy-2(1H)-pyridinone or 3-hydroxy-4(1H)-pyridinone derivatives useful as reactive oxygen species (ROS) scavengers | Cerebrus Pharmaceuticals Limited (GB) | 2000-06-07 | — | — | EP | disclosed |